A gene change sometimes can cause birth defects and other health conditions. This means the gene change that causes Marfan syndrome is passed from parent to child. Only babies who get the gene change have Marfan syndrome. If you or a family member has Marfan syndrome, talk to a genetic counselor to learn more about the chances of your baby having it. Get expert tips and resources from March of Dimes and CDC to increase your chance of having a healthy, fully-term pregnancy and baby.
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Marfan syndrome. E-mail to a friend Please fill in all fields. Please enter a valid e-mail address. Thank you! Your e-mail was sent. Save to my dashboard Sign in or Sign up to save this page. Saving Just a moment, please. You've saved this page It's been added to your dashboard. In This Topic. What is Marfan syndrome? Learn how to prevent or reduce complications in the future.
If you are thinking about becoming pregnant, discuss the possible risks with your doctor. How often you need to see your doctor for follow-up care will depend on your treatment and symptoms. Return to Treatment to review possible treatment options for Marfan syndrome. People who have Marfan syndrome may need more than one heart or blood vessel surgery over time. After surgery, you may need medicines and regular monitoring.
Follow all medical instructions given by your doctor. Recovery after open surgery may take months. To help prevent complications from Marfan syndrome, your doctor may recommend you avoid the following:. Living with Marfan syndrome may cause fear, anxiety, depression, and stress. Talk about how you feel with your healthcare team. Your doctor may recommend:. If you have Marfan syndrome, you are at risk for a life-threatening aortic dissection. If your aorta is weaker or larger than normal, it is important to know the signs and symptoms of a dissection or rupture, which may include:.
Many women who have Marfan syndrome have safe and healthy pregnancies and deliveries. However, there are some added risks during pregnancy and delivery. The most serious risk is aortic dissection due to extra strain on the heart. If you have Marfan syndrome and have already experienced aortic dissection, it is not safe for you to become pregnant.
If you are thinking about getting pregnant, talk with an obstetrician, a doctor who cares for pregnant women, who is familiar with your condition and has experience with high-risk pregnancies.
Your doctor might recommend that you have surgery to fix your aorta before you try to get pregnant. Your doctor will also make sure that your medicines are safe to take during pregnancy. We are committed to advancing science and translating discoveries into clinical practice to promote the prevention and treatment of heart, lung, blood, and sleep disorders, including Marfan syndrome. Learn about current and future NHLBI efforts to improve health through research and scientific discovery.
Learn about the following ways the NHLBI continues to translate current research into improved health for people with Marfan syndrome. Learn about some of the pioneering research contributions we have made over the years that have improved clinical care. In support of our mission , we are committed to advancing research into vascular and genetic diseases, including Marfan syndrome, in part through the following ways.
We lead or sponsor many studies aimed at preventing, diagnosing, and treating heart, lung, blood, and sleep disorders. See if you or someone you know is eligible to participate in our clinical trials. Learn more about participating in a clinical trial.
View all trials from ClinicalTrials. Visit Children and Clinical Studies to hear experts, parents, and children talk about their experiences with clinical research. After reading our Marfan Syndrome Health Topic, you may be interested in additional information found in the following resources. Marfan Syndrome.
Also known as MFS. Marfan syndrome is a genetic condition that affects a protein in the body that helps build healthy connective tissues. Connective tissues support the bones, muscles, and organs in your body and allow your skin, blood vessels, and ligaments to stretch. Some people who have Marfan syndrome have few or no signs or symptoms, while others experience serious symptoms or life-threatening complications. Symptoms of Marfan syndrome depend on which parts of the body are affected and the severity of the condition.
People who have Marfan syndrome may be tall and thin with long arms, legs, fingers, and toes, as well as flexible joints. The most serious complications are problems in the heart and blood vessels, such as weakening or bulging of the aorta. Your doctor may recommend medicines, surgery, or other treatments to manage or prevent complications. Limiting certain activities, or changing how you do them, may help reduce or prevent complications in the heart, eyes, and joints.
Explore this Health Topic to learn more about Marfan syndrome, our role in research and clinical trials to improve health, and where to find more information. Causes - Marfan Syndrome. How is Marfan syndrome inherited? Inheritance Pattern for Marfan Syndrome. This image shows how FBN1 genes are inherited. A person inherits two copies of the FBN1 gene, one from each parent.
If one parent has Marfan syndrome, each child has a 50 percent chance of inheriting a mutated FBN1 gene and having Marfan syndrome.
What does fibrillin-1 do? Read more. Read less. Risk Factors - Marfan Syndrome. Marfan syndrome affects people of all races and ethnicities and men and women equally. Screening and Prevention - Marfan Syndrome. Genetic testing. Prevention strategies.
Signs, Symptoms, and Complications - Marfan Syndrome. Signs and symptoms. Signs and symptoms of Marfan syndrome may include: A chest that sinks in or sticks out A long head with deep-set eyes A tall, thin build Eye problems, including blurred vision or trouble seeing things that are far away.
Retinal detachment is often accompanied by flashes and floaters in your vision. Viewed from the side, the normal spine takes the form of an elongated S, the upper back bowing outward and the lower back curving slightly inward. Viewed from behind though, the spine should appear as a straight line from the base of the neck to the tailbone. Scoliosis is a sideways curvature of the spine. Marfan syndrome can interfere with the normal development of the ribs, which can cause the breastbone to either protrude or appear sunken into the chest.
Because Marfan syndrome can affect almost any part of your body, it may cause a wide variety of complications. The most dangerous complications of Marfan syndrome involve the heart and blood vessels. Faulty connective tissue can weaken the aorta — the large artery that arises from the heart and supplies blood to the body.
Marfan syndrome increases the risk of abnormal curves in the spine, such as scoliosis. It can also interfere with the normal development of the ribs, which can cause the breastbone to either protrude or appear sunken into the chest. Foot pain and low back pain are common with Marfan syndrome. Marfan syndrome can weaken the walls of the aorta, the main artery that leaves the heart.
During pregnancy, the heart pumps more blood than usual. This can put extra stress on the aorta, which increases the risk of a deadly dissection or rupture. Marfan syndrome care at Mayo Clinic. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. This content does not have an English version. This content does not have an Arabic version. Overview Marfan syndrome is an inherited disorder that affects connective tissue — the fibers that support and anchor your organs and other structures in your body.
Finger length in Marfan syndrome Open pop-up dialog box Close. Finger length in Marfan syndrome People who have Marfan syndrome typically have especially long fingers. Longer arms in Marfan syndrome Open pop-up dialog box Close. Know the Signs of an Aortic Aneurysm and Dissection. View factsheets, ask a question, and even connect with other caregivers to get all the information and support you need to care for someone living with Marfan syndrome.
Decisions about family planning can be difficult and very emotional when one of the prospective parents has a genetic disorder, such as Marfan syndrome. Before making any decisions, parents should understand the many options now available, as well as the potential risks to the child and the mother.
A genetic counselor can discuss the options with you and provide insights. Still, there are no guarantees. The most serious of these problems involve the heart and blood vessels, but there are other problems involving the eyes and lungs that also need emergency treatment. To help prepare you for these situations, we recommend that you complete our Emergency Preparedness Kit, which we created specifically for people with Marfan syndrome and related conditions.
It includes our Emergency Alert Card which you can download and carry in your wallet. You can click below to download them. Help us create a world in which everyone with these conditions can live their best life.
What are the Key Features of Marfan Syndrome? Know the Signs of Marfan Syndrome. Download Marfan Syndrome Fact Sheets. Eyes, Head and Neck. What Causes Marfan Syndrome? Getting Diagnosed with Marfan Syndrome Marfan syndrome is a serious, potentially life-threatening condition, and an early, accurate diagnosis is essential for people with Marfan syndrome. Learn More. How is Marfan Syndrome Managed?
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